If you found out you were dying of a terminal illness and only had a few weeks to live would you: A) go on a cross-country trip of self discovery, B) search for your grade school crush, or C) go to a karaoke/strip-club/roller-disco? For Joe the answer is D) all of the above. In the not so distant future, Joe travels out on the road through an absurd world of talking tombstones and strange mutant TV news anchors. Armed with a pack of prescription lollipops and joined by doomsday cult escapee Seth, Joe sets off in search of his beloved Joyce. Of course, he finds much more than he could ever imagine.