Local businessman Grant Grant--successful, albeit oafish--is one of the few leaders of Wheelsy's pack. With beautiful young wife Starla, a large house and fat bank account, Grant truly relishes his "big fish-small pond" role in the town. Other than the fact that the passionate love he feels for his woman goes completely unrequited, he's a man content. But things are about to change for Grant. On a humdrum evening, Grant hits the local honky-tonk for an all-night bender. There he encounters Brenda Gutierrez, the younger sister of an old girlfriend, who's more than willing to listen to Grant's woes. Abandoning their drinks for a moonlight stroll, the pair discovers something slimy in the woods behind the bar. Near the remains of what appears to be a meteor, they find a trail of glistening, noxious ooze and a pulsating, unidentifiable mass. Suddenly, the glob comes to life and overtakes Grant, penetrating his body with a pustule-covered tentacle. An alien parasite has found and infected its unlucky human host, an unwilling transporter who now must continue to infect others in order to survive. Signs of Grant's transformation are instantly apparent: most gruesomely, the denizens begin to suspect Grant's involvement in an unusual number of missing pets and farm animals around town. With each day that passes, Grant becomes less and less human, evolving into a bloodthirsty creature driven by a primal need to kill and destroy the uninfected. Unfortunately, Grant's not the only problem. He has begun spawning scores of giant slugs that are out to inoculate any redneck into whom they can get their siphons. Now joining Starla on her quest to stop Grant and the infected is her former high school beau, local Chief of Police Bill Pardy. A handsome everyman with a burning love for Starla, Pardy gets suspicious of his old rival and leads the charge to take him down. The pair gathers a makeshift crew of uninfected, including foul-mouthed Mayor Jack MacReady and smart-ass teen beauty Kylie Strutemyer to help stop the evil plague laying siege to Wheelsy. But when the ragtag team comes face-to-face with an ancient, vengeful entity beyond all human comprehension, fierce alliances will be forged, former friends will be destroyed and a hilariously gruesome showdown will take place--hillbilly style.