Manu, a hardened young waif, is violently raped by a group of savage young thugs. Nadine, a tough-skinned cocaine addicted prostitute, sells her body but refuses to give up her soul. While sex plays a pivotal and often destructive role in both their lives, they are united by chance and together, as fellow lost souls, they decide to alter their destinies. Angry at the world, but mostly at men, Manu and Nadine embark on a twisted rage-filled road trip. As they travel through France they become deadly harbingers of death and destruction, their relentless bloodlust leaving a trail of dead bodies and mischief. Their random acts of violence mount at an alarming rate and finally they snag the attention of the media and the police.