Pursuit of Happiness (2001)

Ad executive Alan Oliver--a man who's fed up with his job and frustrated by a series of empty, failed relationships--finally realizes that romantic fulfillment is right under his nose--in the form of Marissa Kiley, his best friend from kindergarten. Alan's fanciful chase after the mercurial Tracy Jennings is countered by Marissa's realization of her unhappy marriage to Paul, a co-worker of Alan's. From these journeys, Alan and Marissa learn to trust the inherent power and bonds of friendship.