While a "rebellious" all-night disk jockey plays the blues instead of country music (much to the chagrin of his station manager) various sets of listeners tune into his broadcast while while driving through the desolate Southwest. They include: an unemployed clown and his trashy girlfriend, two feuding sisters, one yuppie nightmare and his salt-of-the-earth companion, and a young Navajo woman with her dying grandmother. They're all so busy bickering and pseudo-philosophizing that none are prepared to deal with the fiery highway collision that is fast approaching, not to mention the serial killer on the loose.