Acomedy about Aids isn't a contradiction in terms. Paul Rudnick, adapting his off-Broadway hit, deftly blends uproarious fun and touching gravity. Jeffrey (Steven Weber) waits tables and looks for acting jobs. He's off sex now that it kills. Then he meets hot, HIV-positive Steve (Michael T. Weiss), who is eager to talk him into bed and a relationship.

The film is a series of vignettes that show Jeffrey trying to overcome his fear with help that includes a televangelist (Sigourney Weaver) and a…