Trish and her younger brother Darry are driving home for Spring break -- it's a routine road trip home from college, with the siblings bickering and enjoying the drive. They recall a spooky tale of a teenage couple from their old high school who disappeared twenty years earlier along the same stretch of road that they are on. As the story goes, they found her body but they never found him...or her head. Later, driving past an old church, they see a mysterious cloaked figure, who chases them before vanishing. Soon, their road trip is turning into a heart-stopping race for their lives, as they find themselves the prey of an indestructible force that relentlessly pursues them and gives a new and chilling meaning to the old song "Jeepers Creepers".