Sisters-in-law and best mates Dawn and Jackie work at a factory in a small Lancashire town. At one of their regular bingo sessions, Dawn wins the 100,000 pound National Jackpot. But their celebrations are cut short when Dawn discovers that the breast cancer she thought she had beaten has now returned and spread. Unwilling to waste what little time she has left, Dawn and Jackie leave everthing behind and head off to Las Vegas to fulfill a life-long dream. While in Vegas, Dawn's winning streak continues when she hits the jackpot on her first slot machine. As the dollars tumble on the floor, she is approached by an American cowboy named Cody who promptly leads them on the most incredible adventure of their lives.