Journalist Ann Bauer discovers a secret project while covering a story in the Brazilian rainforests, a container of deadly bees, genetically-engineered as biological weapons by a scientist named Dr North. The bees, destined for New York City where they will wreak havoc, are inadvertently released on its cargo plane, but it is up to the plane's passengers, including Ann's ex-husband, Marty, to stop the threat of the bees before they reach the city. Ann, meanwhile, must try and stop Dr North while contending with a shadowy figure, Ezekial, who wishes to control the bees himself.