Final Fantasy: the Spirits Within (2001)

The year is 2065 and Earth is under siege. A meteor has crashed onto the planet, unleashing millions of alien creatures which roam the Earth. Decimating field and city alike, these predators are threatening to extinguish all life on the planet. The survivors of the initial onslaught have retreated to barrier cities built to protect the inhabitants of Earth from the marauding invaders. But the few cities around the globe are in decline and time is running out. Yet the sprit of humankind is resilient and embodied in the brilliant and beautiful Dr. Aki Ross. Determined and capable, Aki strives as Earth's last hope against extinction. With the guidance of her scientific mentor, Dr. Sid, and the aid of the Deep Eyes military squadron led by the courageous Captain Gray Edwards, Aki races to save both the Earth and herself. But her quest is jeopardized by the militant opposition of General Hein, who plots to unleash a massive space cannon that will annihilate the aliens and possibly the Earth.