While supporting herself as a "chargirl" in London, keeping houses for the wealthy, including the great granddaughter of pre-Raphaelite painter William Hollman Hunt, founded the American Repertory Theatre with other American actors; produced productions like "Hot L Baltimore" and "Archie and Mehitabel"

US TV-movie debut, "Rona Jaffe's 'Mazes and Monsters'" (ABC)

Met husband Michael Murphy when the two starred in the short-lived CBS crime series "Hard Copy"

Played first mistress to Presidential candidate Jack Tanner (Michael Murphy) in HBO's critically-acclaimed series "Tanner '88", directed by Robert Altman

First feature released in theaters, "The Doctor", starring William Hurt

First significant feature role, mother of evil Macauley Culkin, in "The Good Son"

Assumed the role of Susan Silverman in a pair of TV movies reviving Robert Urich's "Spenser For Hire" TV character

Played Tim Allen's ex-wife in "The Santa Claus"

Played Roberta Crachit in the Lifetime TV-movie "Ebbie", a gender-bent "A Christmas Carol", starring Susan Lucci in title role

Appeared in "To Gillian on Her 37th Birthday"

Portrayed Harrison Ford's wife, the First Lady, in "Air Force One"

Co-starred in "Gang Related"

Played Faye Stafford in the Tom Hanks-produced HBO miniseries "From the Earth to the Moon"

Co-starred in "Better Than Chocolate"

Appeared as "Ma'am" in the Robin Williams film "Bicentennial Man"

Produced and starred in the romantic comedy "Suddenly Naked"

Appeared as Arnold Schwarzenegger's wife in "The 6th Day"

Played widowed detective Joanne Killborne, novelist Gail Bowen's recurring heroine, in a series of Lifetime telepics entitled "Criminal Instinct"

Starred alongside Sidney Poitier in the CBS TV movie "The Last Brickmaker in America"

Played Maggie Steech in ABC's summer series "The Beast"

Cast in the ensemble independent film "Between Strangers" (lensed 2001)

Appeared in the telepic "The Matthew Shepard Story"

Reprised her role for "The Santa Claus 2"

Joined the cast of Fox's "24" in a recurring role as Dr. Anne Packard

Cast in the thriller "The Clearing" which starred Robert Redford and Helen Mirren

Reprised role as Tim Allen's ex-wife in "The Santa Clause 3: The Escape Clause"

Co-starred with husband, Michael Murphy in Sarah Polley's directorial debut, "Away From Her"