Began her stand-up comedy career when she entered a Washington D.C. area talent competition

Joined the writing staff and cast of the HBO series "The Chris Rock Show"

Made film debut in "Tomorrow Night"; directed by "The Chris Rock Show" co-writer, Louis C.K.

Acted in "Nutty Professor II: The Klumps"

Re-teamed with Rock in "Pootie Tang" (based on a sketch from Rock's show) and "Down to Earth"

Was a regular on the NBC midseason replacement series "The Downer Channel"

Played a recurring role on Larry David's HBO series "Curb Your Enthusiasm"

Voiced a recurring character named Gladys on Comedy Central's puppet show "Crank Yankers"

Cast in her own FOX sitcom "Wanda at Large"

Appeared in the hour-long Comedy Central special "Tongue Untied"

Starred in her own short-lived Comedy Central show "Wanda Does It"

Penned a book of humorous observations on various topics, Yeah, I Said It

Cast as Jane Fonda's long-suffering personal assistant in the comedy "Monster-in-Law"

Landed a recurring role on "The New Adventures of Old Christine" (CBS); became a series regular in the second season

First HBO Comedy Special, entitled "Wanda Sykes: Sick & Tired"

Cast opposite Steve Carell in "Evan Almighty," a sequel to the 2003 comedy "Bruce Almighty"