Raised in Amherst, Massachusetts

Lived in a artists' colony in Woodstock, New York

Moved to Manhattan to attend the Professional Children's School

Film debut in "Kiss Daddy Goodnight"

First gained acclaim with her role as the virginal Cecile in "Dangerous Liaisons"

Played Venus in "The Adventures of Baron Munchausen"

Starred as the wife of writer Henry Miller in "Henry & June"; first film to receive the NC-17 rating

TV-movie debut in "Robin Hood" (Fox)

Had leading role of Sissy Hankshaw in the ill-fated film version of "Even Cowgirls Get the Blues"

Earned a Best Supporting Actress Oscar nomination playing a gangster's wife in Quentin Tarantino's "Pulp Fiction"

Offered a fine comic turn as a ditzy model in "The Truth About Cats and Dogs"

Delivered a scene-stealing turn as the villainous Poison Ivy in "Batman & Robin"

Starred opposite future husband Ethan Hawke in the futuristic thriller "Gattaca"

Played Fantine in Bille August's remake of "Les Miserables"

Cast as Emma Peel opposite Ralph Fiennes' John Steed in the feature version of "The Avengers"

Played the second wife of a jazz musician (Sean Penn) in Woody Allen's "Sweet and Lowdown"

Co-starred with husband Ethan Hawke and Robert Sean Leonard in the Richard Linklater directed "Tape"; received an Independent Spirit Award nomination for Best Lead Actress

Co-starred (also executive produced) with Juliette Lewis in the HBO produced, "Hysterical Blindness"; film first screened at Sundance; received a SAG nomination for Best Actress in a TV movie

Had featured role in the Ethan Hawke-directed "Chelsea Walls" (filmed in 1999)

Re-teamed with Tarantino to portray a female assassin who awakens from a four-year coma and seeks revenge on her former boss; film released in two Volumes "Kill Bill Vol. 1" (2003) and "Kill Bill Vol. 2" (2004); received Golden Globe nominations for Best Actress for Vol. 1 (2003) and Vol. 2 (2004)

Played the love interest to Ben Affleck's character in the thriller "Paycheck"

Chosen as the new face of Louis Vuitton, for their Spring 2005 campaign

Re-teamed with her "Pulp Fiction" castmate, John Travolta in "Be Cool"

Played a woman in her late thirties romancing a younger man in Ben Younger's "Prime" opposite Meryl Streep

Starred as Swedish secretary Ulla, in the movie-musical version of "The Producers"

Played a superhero who gets revenge on the boyfriend that dumped her in Ivan Reitman's "My Super Ex-Girlfriend"

Portrayed a grown Diana in Vadim Perelman's "The Life Before Her Eyes"

Will co-star with Colin Firth and Jeffrey Dean Morgan in the romantic comedy "The Accidental Husband"