Raised in Los Angeles

Began modeling at age 14, after being discovered by a fashion photographer

Appeared in numerous stage productions at the Macowan Theater in London

Made guest appearances on two episodes of ABC's "Happy Days" (billed as Margarita Ibrahimoff)

TV-movie debut, "Flying High"

Feature film debut, "Cheech & Chong's Next Movie"

Guest starred on future husband's sitcom, "Bosom Buddies" (ABC)

First recurring role on a TV series, playing Nurse Lacey on "M*A*S*H" (CBS)

First starring role in a feature, "Volunteers"; cast opposite future husband Tom Hanks

Cast as a PR woman in "The Bonfire of the Vanities"

Cast opposite real life husband Tom Hanks in Nora Ephron's "Sleepless in Seattle"

Again teamed with Ephron for "Mixed Nuts"

Co-starred with Rosie O'Donnell, Melanie Griffith and Demi Moore in the coming of age drama "Now and Then"

Cast opposite Arnold Schwarzenegger in the comedy "Jingle All the Way"

Played Susan Borman, wife of astronaut Frank Borman, in the HBO miniseries "From the Earth to the Moon"; husband Tom Hanks directed, produced and scripted

Cast as Richard Gere's ex-wife in "Runaway Bride"

Withdrew from the cast of Neil Simon's play "The Dinner Party" due to 'creative differences'

Acted in the LA premiere of the Pulitzer-winning "Dinner With Friends"

Co-produced (with Hanks) Nia Vardalos's feature adaptation "My Big Fat Greek Wedding"; was the driving force behind the film, which became the highest-grossing independent film of all time

Played Bob Crane's wife (Greg Kinnear) in "Autofocus"

Produced the short-lived CBS series "My Big Fat Greek Life"; also starring Nia Vardalos

Co-starred in Arie Posin's darkly satiric feature "The Chumscrubber"

Performed the role of Roxie Hart in the Broadway revival of "Chicago"

Executive produced (with husband Tom Hanks) the film adaptation of the West End stage musical, "Mamma Mia!"