Made acting debut in the ABC TV-movie "I'll Take Romance"

Played a supporting role opposite Rutger Hauer in the USA Network thriller "Past Midnight"

Made feature debut in Cameron Crowe's "Singles"

Had a small role in Woody Allen's "Mighty Aphrodite"

Appeared opposite brother Marcus in the Off-Broadway play "The Blues Are Running"

Featured as an FBI Technician in Mike Newell's "Donnie Brasco"

Breakthrough role, playing Kenny 'Pig Vomit' Rushton, Stern's antagonistic program director at WNBC in the film adaptation of Howard Stern's "Private Parts"

Played the spineless brother in the Broadway production of "The Three Sisters"

Portrayed Civil War veteran, Jeremiah Piper in ABC's "Tourist Trap"

Appeared as the Control Room Director in Peter Weir's "The Truman Show"

Played Jimmy Tomorrow in the Broadway revival of Eugene O'Neill's "The Iceman Cometh"

Played Kaufman's creative partner, Bob Zmuda in the Andy Kaufman biopic "Man on the Moon"; directed by Miloš Forman

Provided comic relief as the ape who trafficks in humans in Tim Burton's "Planet of the Apes"

Cast as a film producer in "Big Fat Liar" opposite Frankie Muniz and Amanda Bynes

Played the lead role in the Harvey Pekar biopic, "American Splendor"; earned an Independent Spirit Award nomination

Cast opposite Ben Affleck in John Woo's "Paycheck"

Played Miles Faymond, a divorced struggling writer in Alexander Payne's "Sideways"; earned Golden Globe and SAG nominations for Actor in a Leading Role

Portrayed manager/trainer Joe Gould, opposite Russell Crowe in "Cinderella Man"; earned Oscar and Golden Globe nominations for Actor in a Supporting Role

Cast as the lead in M. Night Shyamalan's supernatural thriller "Lady in the Water"

Portrayed the shrewd Chief Inspector Uhl in Neil Burger's "The Illusionist"

Portrayed Santa Claus in the comedy "Fred Claus" co-starring Vince Vaughn as his disgruntled older brother

Played the title role in the seven part HBO miniseries, "John Adams"; earned an Emmy nomination for Best Actor in a Miniseries or TV-Movie