Sandy-haired, brown-eyed actor Michael DeLuise grew up the middle child in a family of entertainers, consisting of his comedian-actor father Dom, his actress mother Carol Arthur and older brother Peter and younger brother David, both actors. Possessed of a wealth of experience that belies his relative youth, DeLuise was making his own 8 mm movies at age 7 before he appeared in his first feature, "Hot Stuff" (1979), a real family affair which starred his father and had roles for his mother and brothers too. After that, his parents refused to allow him to work professionally until he began to drive. His first small-screen part came as series regular Brian Hatton on the syndicated sitcom "One Big Family" (1986-87), starring Danny Thomas, and he followed with a recurring role on "Eisenhower & Lutz" (CBS, 1988). Since then DeLuise has appeared frequently as a series regular, including a stint playing brother to real-life sibling Peter during the final season of "21 Jump Street" (1989-90) and a season and a half as Tony Piccolo on "seaQuest DSV" (NBC, 1994-95), starring Roy Scheider.

Primarily a TV actor, DeLuise has found time for feature film portrayals like Alan in "Wayne's World" (1992) and deranged 19-year-old killer Darryl Weston in "Midnight Edition" (1994), among others. An aspiring filmmaker, he has directed two straight-to-video releases, his debut "Almost Pregnant" (1992) and the follow-up "Prime Time Murder" (1992), and served as executive producer and director for the as-yet-unreleased "Between the Sheets", written by and starring his brother Peter. He achieved perhaps his most visible profile for his critically-acclaimed recurring role of Andy Sipowicz Jr (Dennis Franz's son) in ABC's hit cop series "NYPD Blue". Beginning with Andy Jr's first appearance in 1993 and ending with his tragic death trying to stop a hold-up in a 1997 episode, the compelling father-son storyline served the show well, broadening (by softening) Franz's character. The fall of 1997 introduced him once again as a series regular, Officer Phil Roussakoff on CBS' "Brooklyn South", produced by "NYPD Blue" honcho Steven Bochco.