Moved to New York to continue stage career

Broadway debut, "Cactus Flower"

Film debut in "Hot Rod Hullabaloo"

Played Judith Cole on daytime soap, "Love of Life" (CBS)

Landed role in Norman Mailer's Off-Broadway play "The Deer Park"

Portrayed Nurse Marsha Lord in syndicated TV series "Young Dr Kildaire"

Received first of four Best Actress Oscar nominations for "Cinderella Liberty", co-starring James Caan

Appeared on Broadway in Neil Simon's "The Good Doctor"; later married the playwright

Appeared in the PBS "Great Performances" production of "Cyrano de Bergerac"

Starred in Robert Wise's reincarnation thriller "Audrey Rose"

First feature role in a film with a Neil Simon screenplay, "The Goodbye Girl"; earned Best Actress Oscar nomination

Reunited with James Caan in "Chapter Two", adapted by Simon from his stage play; third Academy Award nomination as Best Actress

Earned fourth Best Actress Oscar nomination as an alcoholic actress in "Only When I Laugh"

Network TV movie debut in "Lois Gibbs and the Love Canal" (CSB)

Last of five feature film collaborations with husband-screenwriter Neil Simon, "Max Dugan Returns"

Acted opposite Clint Eastwood, playing his foul-mouthed ex-wife struggling to survive by pushing drinks in a town bar, in "Heartbreak Ridge"

Directed "Juno's Swans" at NYC's Second Stage Theatre

TV directorial debut, the "CBS Schoolbreak Special" entitled "Little Miss Perfect"

Appeared in the TNT remake of "Dinner at Eight"; cast opposite John Mahoney

Starred in short-lived ABC-TV series, "Sibs" (also known as "Grown-Ups")

Played Governor Eleanor Grant, the target of assassination, in "Nick of Time", starring Johnny Depp

Returned to NYC stage in Tennessee Williams' "Night of the Iguana"

Appeared in the feature film "2 Days in the Valley"

Had recurring role of Sherry, the blowsy girlfriend of Martin Crane (John Mahoney), on NBC sitcom "Frasier"

Reteamed with Richard Dreyfuss on stage in "House", produced on Long Island, New York

Co-starred with Dreyfuss in London production of Neil Simon's play "The Prisoner of Second Avenue"

Cast as Ethel Gumm in the ABC miniseries "Me and My Shadows: Life With Judy Garland", based on Lorna Luft's memoir

Cast as Mr. Darcy's mother in "Bride and Prejudice" Gurinder Chadha's Bollywood update of Jane Austen's classic tale