Appeared in several nationally broadcast commercials

Made TV debut as regular on FOX's "In Living Color"

Made feature debut, opposite brother Damon Wayans, in "Mo' Money"

Featured in the basketball drama, "Above the Rim"

Co-created and co-starred, with brother Shawn, in the WB sitcom "The Wayans Bros."

First produced feature, "Don't Be a Menace to South Central While Drinking Your Juice in the Hood"; also co-wrote and starred in the film

Played the lead in the comedy "Senseless"

Co-wrote and co-starred in the box-office hit "Scary Movie"

Offered a dramatic turn as a drug user in Darren Aronofsky's "Requiem for a Dream"

Again portrayed Shorty Meeks in "Scary Movie 2"

Joined Tom Hanks for the Coen brothers' remake of "The Ladykillers"

Co-wrote and co-starred with brother Shawn, as FBI agents that go undercover as hotel heiresses, in "White Chicks" directed by brother Keenen Ivory Wayans

Co-created (with Keenen and Shawn) the Nickelodeon animated series, "Thugaboo"

Co-wrote and co-starred with brother Shawn in the comedy, "The Little Man"; directed by brother Keenen Ivory Wayans

Featured in the Eddie Murphy comedy, "Norbit"

Co-produced and co-wrote "Dance Flick" with brothers; directed by nephew Damien Dante Wayans

Cast as Ripcord in the big-screen version of "G.I. Joe: The Rise of Cobra"