Hosted the children's show, “Steampipe Alley”

Feature debut in Robert Redford’s “Quiz Show”

Broadway debut in Terrence McNally’s “Love! Valour! Compassion!”; replaced Nathan Lane in the role of Buzz

Headlined “Comedy Central Presents Mario Cantone”

Earned praise for his work as a gay alcoholic in the stage play "The Crumple Zone"

Breakthrough role as Charlotte's gay friend Anthony on the HBO comedy "Sex and the city"

Performed in his first one-man show, “An Evening with Mario Cantone”

Had a memorable bit on “Chappelle’s Show” (Comedy Central) in a segment entitled “Ask a Gay Dude”

Appeared on Broadway in Richard Greenberg's “The Violet Hour”

Cast as would-be Nixon assassin Samuel Byck in the Tony award winning musical “Assassins” directed by Joe Mantello

Re-teamed with director Joe Mantello for his second one-man show, “Laugh Whore”

Contributed to the all-star comedian line-up in Penn Jillette and Paul Provenza’s documentary, “The Aristocrats”

Voiced Sidney in the mockumentary, “Farce of the Penguins”

Voiced surf nut Chicken Joe in the animated feature, "Surf's Up"

Reprised role as Charlotte's gay friend Anthony for "Sex and the City: The Movie"