Raised in Edwardsville, Illinois

Original member of Steppenwolf Theatre Company in Chicago

Cast member of TV series, "Saturday Night Live"

Went to New York with Steppenwolf production of "Balm in Gilead"

Feature film debut, "Desperately Seeking Susan"

TV movie debut, "The Execution of Raymond Graham"

Played the title character's younger sister, Jackie on the ABC sitcom "Roseanne"; earned Emmy (1995) and Golden Globe (1993, 1995) nominations for Best Supporting Actress

Broadway debut, "My Thing of Love"

Had pivotal role in "Scream 2"

Starred opposite Norm Macdonald in ABC's "Norm/The Norm Show"

Cast as a psychiatrist in Mike Figgis' experimental "Time Code"; not seen in theatrically released version; replaced by Glenne Headley; will be included on the DVD release

Starred in the L.A. premiere of "Looking for Normal"

Replaced Julie Walters in the London stage production of "All My Sons"

Earned an Emmy nomination for Best Guest Actress in a Comedy Series for "Monk"

Co-starred in the comedy, "Artie Lange's Beer League"

Guest starred on ABC's "Desperate Housewives" as meddling neighbor Carolyn Bigsby; earned an Emmy nomination for Outstanding Guest Actress in a Comedy Series

Cast in the Garry Marshall-directed dark comedy "Georgia Rule"

Cast opposite Nathan Lane in the Broadway production of David Mamet's "November"; received a Tony award nomination for Featured Actress in a Play