Name: Katherine Heigl

You've Seen Her In:
Knocked Up, 27 Dresses, Grey's Anatomy

Pros:
She's already been labeled "The Next Julia Roberts." That helps. The $76 mil 27 Dresses pulled in last year doesn't hurt either. She likes to speak her mind too and that garners respect.

Cons:
She likes to speak her mind and that annoys some people.

Box-Office Bonafides
1. Knocked Up -- $219m
2. 27 Dresses -- $160m

Accolades
Grey's Anatomy -- Two Golden Globe Nominations for Best Actress

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