Moved to USA at age four; grew up in Manhattan

Made screen debut in small role in "Anne of a Thousand Days", starring her father

Made New York stage debut in "Present Laughter"

Starred in title role in Off-Broadway production of "Alice in Wonderland"; recreated role for PBS version which also featured her father

Made stage musical debut in "Doonesbury"

Co-starred with her father in the CBS miniseries "Ellis Island"

Had featured role in "Big Trouble in Little China"

Played mother in NBC series "Home Fires"

Appeared as Henry Winkler's wife in the short-lived Fox sitcom "Monty"

Starred in "Notes for My Daughter", an "ABC Afterschool Special"; won Daytime Emmy for performance

Had featured role in L.A. production of Tom Stoppard's "Arcadia"

Played the recurring role of a district attorney in the legal drama "The Practice" (ABC)

Returned to Broadway succeeding Kate Nelligan in "An American Daughter" (June)

Had supporting role in Woody Allen's "Celebrity"

Assumed leading role in the Broadway production of "The Beauty Queen of Lenane"

Reprised role in Irish staging of "The Beauty Queen of Lenane" in Waterford

Received rave reviews for her turn as "Hedda Gabler", produced on Broadway

Co-starred as Mrs. Kendal in the Brodway revival of "The Elephant Man", starring Billy Crudup

Cast opposite Diane Lane in Adrian Lyne's "Unfaithful"

Cast in the HBO mini-series "Empire Falls" based on Richard Russo's novel

Appeared with Naomi Watts and Ryan Gosling in Marc Forster's "Stay"

Portrayed Meredith's (Ellen Pompeo) mother, an ex-surgeon who suffers from Alzheimer's Disease on the ABC medical drama "Grey's Anatomy"; earned an Emmy nomination in 2006 and 2007 for Outstanding Guest Actress in a Drama Series

Starred in the revival of W. Somerset Maugham's "The Constant Wife"; earned a Tony nomination for her performance