Moved to New York (date approximate)

TV debut as Carmen on daytime soap opera "Edge of Night"

Played Frannie Hughes on CBS daytime serial "As the World Turns"; eventually played dual role of Frannie and her lookalike half-sister Sabrina

Primetime TV debut in the CBS miniseries "I'll Take Manhattan"

Cast as Ophelia in a production of "Hamlet" at the Guthrie Theatre

TV-movie debut, "Money, Power, Murder" (CBS)

Feature acting debut, "Tales From the Darkside: The Movie"

Met Andre Gregory while appearing in "Ice Cream With Hot Fudge" at The Public Theater in NYC

Cast as Yelena in Gregory's workshop of "Uncle Vanya" (date approximate)

First substantial role in a feature as the real estate agent friend to Annabella Sciorra in "The Hand That Rocks the Cradle"

Caught the attention of Steven Spielberg with her three minute role as a doctor colleague of Harrison Ford's Dr. Richard Kimble in "The Fugitive"

First film for Robert Altman, "Short Cuts"; garnered notoriety for a scene performed nude from the waist down

Worked with Al Pacino in a stage workshop production of August Strindberg's "The Father"

Recreated the role of Yelena for Louis Malle's "Vanya on 42nd Street," a filmed version of Gregory's workshops

First leading role in a feature, "Safe"; also first pairing with director Todd Haynes

Cast as Dora Maar in the Merchant-Ivory film "Surviving Picasso"

Co-starred in the blockbuster sequel "The Lost World: Jurassic Park"

Played Mia, the uptight daughter in a highly dysfunctional family in Bart Freundlich's "The Myth of Fingerprints"; fell in love with film's director and later married

Received first Academy Award nomination as Best Supporting Actress for her performance as a porn star in "Boogie Nights"

Cast in the Coen brothers' "The Big Lebowski"

Assumed role originated by Vera Miles in Gus Van Sant's shot-for-shot color remake of "Psycho"

Reteamed with Robert Altman to play an eccentric Southerner in "Cookie's Fortune"

Starred opposite Rupert Everett in the period drama "An Ideal Husband"

Played the pious British wife engaging in an adulterous relationship with a writer (Ralph Fiennes) in Neil Jordon's "The End of the Affair"; earned a Best Actress Oscar nomination

Reunited with Paul Thomas Anderson to play the trophy wife of a dying television executive in "Magnolia"

Appeared in the Neil Jordan-directed short film "Not I"

Assumed role of FBI agent Clarice Starling in the sequel "Hannibal"

Co-starred with Billy Crudup in "World Traveler," directed by Bart Freundlich; screened at Toronto Film Festival; shown at 2002 Sundance Film Festival

Acted opposite Kevin Spacey in the film version of the award-winning novel "The Shipping News"

In January, began appearing in TV commercials as a spokesperson for Revlon cosmetics

Had featured role as a Texas housewife in one of the three stories that comprise "The Hours," based on Michael Cunningham's Pulitzer-winning novel and directed by Stephen Daldry; received SAG and Oscar nominations for her supporting role

Reteamed with "Safe" director Todd Haynes to star in "Far From Heaven," as a suburban housewife in the 1950s; received Golden Globe, SAG and Oscar nominations leading role

Starred as Audrey Miller, a divorce lawyer who falls for Pierce Brosnan in the romantic comedy "Laws of Attraction"

Played a mother struggling to cope with the loss of her 8-year-old son in the thriller "The Forgotten"

Portrayed a 1950's mother of ten in Jane Anderson's "The Prize Winner of Defiance Ohio" based on a true story

Played an actress married to would-be philanderer (David Duchovny) in husband Bart Freundlich's "Trust the Man"

Starred in Alfonso Cuaron's futuristic tale, "The Children of Men," adapted from P.D. James' novel

Broadway debut in David Hare's political drama, "The Vertical Hour" directed by Sam Mendes

Co-starred in Todd Haynes' film, "I'm Not There" a film reflecting the life of musician Bob Dylan

Published her first children's picture book, entitled Julianne More: All About Me

Starred in Tom Kalin's controversial incestuous film "Savage Grace"

Co-starred with Mark Ruffalo in director Fernando Meirelles' thriller "Blindness"