Joined Trinity Repertory Company in Providence, Rhode Island after graduating from college

TV debut in "Theater in America" presentation of Trinity Square Repertory's production "Feasting With Panthers"

Had regular role of Carrie Wheeler on the NBC serial "Somerset" (NBC)

Played regular role of Brandy on "Guiding Light" (CBS)

Film acting debut in small role in "Kramer vs. Kramer"

Broadway debut as a replacement in "Moonchildren", co-starring Kevin Kline

Had leading role in the supernatural thriller "Poltergeist"

Co-starred in the ensemble drama "The Big Chill", featuring Kline and Tom Berenger

Played Reve Walsh, the mother of a child who was abducted, in the NBC drama "Adam"; earned Emmy nomination

Acted in the controversial ABC drama "The Day After"

Reprised role in "Poltergeist II: The Other Side"

Again played Reve Walsh in the sequel "Adam: His Song Continues" (NBC)

Co-starred in the

Portrayed Mary Beth Whitehead in the based on fact drama "Baby M" (ABC); received second Emmy nomination

Reportedly turned down the lead in the CBS sitcom "Murphy Brown" which had been created by Diane English with her in mind

Co-starred in "My Name Is Bill W" (CBS)

Had featured role in "Switch" and "Dutch"

Made directorial debut with "On Hope"; earned 1994 Oscar nomination for Best Live Action Short Film

Portrayed Bessie Earp in "Wyatt Earp"

Garnered third Emmy nomination for a guest appearance in "Frasier" (NBC)

Starred in TV series "John Grisham's 'The Client'"

Directed by husband John Paquin in "Jungle2Jungle"

Portrayed astronaut wife Marge Slayton in "From the Earth to the Moon" (HBO)

Returned to series TV as co-star of "Payne" (CBS), a short-lived Americanization of "Fawlty Towers", starring John Larroquette

Co-starred in the ABC movie "Trapped in a Purple Haze"

Directed the Showtime movie "Frankie and Hazel"

Acted in "The Ponder Heart" (PBS)

Co-starred with Sean Patrick Flanery and Melina Kanakaredes in Michael Phelan's "Into the Fire"

Joined the cast of FOX's drama "24" in season five as Agent Henderson’s wife, Miriam

Guest-starred in four episodes of Showtime's serial-killer drama "Dexter"