Professional acting debut with a community theater in Greenville, South Carolina

TV debut in "Penny" an episode of "Robert Montgomery Presents" (NBC)

Appeared frequently on many of the TV anthology series of the 1950s including "Studio One", "Ford Television Theatre" and "Alfred Hitchcock Presents"

Broadway debut as understudy to Kim Stanley and Janice Rule in "Picnic"; met Paul Newman who was in cast

Screen acting debut in "Count Three and Pray"

Had role as a murder victim in the noirish "A Kiss Before Dying"

Won Best Actress Oscar for performance as a a woman with multiple personalities in "The Three Faces of Eve"

First of 10 films (to date) in which she acted alongside Paul Newman, "The Long Hot Summer"; also appeared together in "Rally Round the Flag, Boys!"

Co-starred with Marlon Brando and Anna Magnani in "The Fugitive Kind", a film version of Tennessee Williams' "Orpheus Descending"

Had title role in "The Stripper"

Returned to Broadway in "Baby Want a Kiss"

Starred opposite Sean Connery as his supportive waitress wife in the satirical "A Fine Madness"

Played the wife of a card sharp who replaces him in a poker game in the comic Western "A Big Hand for the Little Lady"

First directed by husband Paul Newman in a film, "Rachel, Rachel"; earned Best Actress Oscar nomination

Cast as a female Dr. Watson treating a man (George C Scott) convinced he is Sherlock Holmes in "They Might Be Giants"; Newman served as a producer

Returned to TV after more than a decade in the "Hallmark Hall of Fame" production of "All the Way Home" (NBC)

Directed by Newman in the film version of the Pulitzer-winning "The Effect of Gamma Rays on Man-in-the-Moon Marigolds"

Picked up third Best Actress Academy Award nomination for "Summer Wishes, Winter Dreams"

Received Emmy nomination for role as a compassionate psychatrist treating a woman with 16 personalities in "Sybil" (NBC), co-starring Sally Field

TV directorial debut with an episode of the ABC drama series "Family"

Starred in TV remake of "Come Back, Little Sheba" (NBC)

Won Emmy Award for performance as a middle-aged housewife who decides to comepete in the Boston Marathon in "See How She Runs" (CBS)

Cast as the ex-wife of a bisexual dying of cancer in the ABC TV adaptation of Michael Cristofer's Pulitzer-winning "The Shadow Box", directed by Paul Newman

Garnered Emmy nomination as an Arkansas teacher in the fact-based CBS drama about the 1957 integration of Central High School in Little Rock in the TV-movie "Crisis at Central High"

Wrote and directed "Come Along With Me", based on an unfinished novel by Shirley Jackson; aired on PBS' "American Playhouse"

Returned to Broadway as star of revival of George Bernard Shaw's "Candida"; production recreated for The Entertainment Channel and aired in 1983

Made cameo appearance in "Harry & Son", written, produced and directed by Paul Newman, who also co-starred

Picked up second Emmy Award as a woman stricken with Alzheimer's disease in "Do You Remember Love" (CBS)

Served as host for the PBS series "American Masters"

Hosted "Live at the Met" on PBS

Portrayed Amanda Wingfield in Newman-directed remake of Tennessee Williams' "The Glass Menagerie"

Co-produced the PBS "American Masters" presentation, "Broadway Dreamers: The Legacy of the Group Theater"; also served as host; program won 1990 Emmy Award as Outstanding Informational Special

Garnered fourth Best Actress Oscar nomination in teh Merchant Ivory production of "Mr. & Mrs. Bridge"; starred opposite Newman

Acted on stage in "Ghosts" at Woodstock, New York

Starred opposite Brian Dennehy in the TNT adaptation of Alison Lurie's novel "Foreign Affairs"

Served as narrator for Martin Scorsese's sumptuous film adaptation of "The Age of Innocence"

Co-produced and starred in "Blind Spot", a CBS "Hallmark Hall of Fame" presentation; played a US congresswoman whose life is upended when she learns her daughter is addicted to cocaine; received Emmy nomination

Last film role to date, as Tom Hanks' mother in "Philadelphia"

Earned yet another Emmy Award nomination starring opposite James Garner as a bickering married couple in "Breathing Lessons", a CBS "Hallmark Hall of Fame" production based on Anne Tyler's award-winning novel; last TV acting role to date

Narrated the documentary "My Knees Were Jumping: Remembering the Kindertransports"; premiered at the San Francisco Jewish Film Festival

Starred in "Arsenic and Old Lace" at the Long Wharf Theatre in New Haven, Connecticut

Directed Off-Broadway production of "Golden Boy" by Clifford Odets the debut offering of the Blue Light Theater Company

Had lead role in a summer theater production of "Hay Fever" in the Berkshires

Staged Clifford Odets' play "Waiting for Lefty" at the Blue Light Theater Company; production featured Marisa Tomei and Greg Naughton

Directed "La Ronde" at the Williamstown Theatre Festival

Appointed as co-chair of the artistic advisory council of the Westport Country Playhouse

Appeared on stage with Paul Newman at the Westport Country Playhouse in A R Gurney's "Ancestral Voices" for one-week run

Starred in one-night only staged reading of "Arsenic and Old Lace", the first in a series of play readings produced by Alec Baldwin (November)

Became artistic director of the Westport Country Playhouse

Earned Emmy, Golden Globe and SAG nominations for her role in "Empire Falls," the HBO adaptation of Richard Russo's novel