Moved with family from Brooklyn to Saugerties, New York as a child

Began stand-up career at age 17

Trained with The Groundlings, Los Angeles' famed comic theater company

Guest starred on "Spin City" (ABC)

Joined the cast of "Saturday Night Live" (NBC) as a featured player

Promoted to regular cast member on "Saturday Night Live" (NBC)

Made feature acting debut in Cameron Crowe's 1970s rock homage "Almost Famous," as manager Dennis Hope

Along with "SNL" writer Tina Fey, co-anchored the series' news segment "Weekend Update"

Appeared in an episode of the HBO miniseries, "Band of Brothers"

Co-hosted the MTV Movie Awards with Kirstin Dunst

Hosted the MTV Music Video Awards

Cast alongside Jason Biggs and Christina Ricci in the Woody Allen comedy, "Anything Else"

First starring role in a feature, "Taxi"

Co-starred, opposite Drew Barrymore, as a crazed Red Sox fan in the Farrelly brothers' comedy, "Fever Pitch"

Appeared opposite Sienna Miller in "Factory Girl"

Was announced that Fallon will take over for O'Brien as the host of "Late Night" when O'Brien succeeds Jay Leno as host of "The Tonight Show"

Hosted 10-minute online webcasts prior to his TV debut in the post-Tonight Show slot

Made his debut as the host of NBC's "Late Night" on March 2