Began acting in summer stock at Williamstown Theater in Massachusetts

Joined the Charles Street Repertory Theater in Boston

Made Off-Broadway debut in "The Sudden and Accidental Re-Education of Horse Johnson"

Made feature debut in "The Wedding Party"; co-directed by Brian De Palma and co-starred Robert De Niro (filmed in 1963 but not released until six years later)

Cast in a regular role on the daytime drama "Search for Tomorrow"

Made Broadway debut in "The Rothschilds"

First major feature film, "Portnoy's Complaint"

Played the title character's wife, Catherine in the Broadway play "Pippin"

Made TV film debut, "Hustling" (ABC); received first Emmy nomination

Featured as Carole Lombard in "Gable and Lombard" and as Gene Wilder's love interest in "Silver Streak"

Paired with Burt Reynolds for the first time in "Semi-Tough"

Breakout performance, Paul Mazursky's "An Unmarried Woman"; garnered first Best Actress Oscar nomination

Played Chrissy in the NYC production of David Rabe's "In the Boom Boom Room"

Earned second Best Actress Oscar nomination for Alan J Pakula's "Starting Over"; second collaboration with Burt Reynolds

Starred opposite Walter Matthau in "First Monday in October"

Delivered a first-rate portrayal of a woman coping with addiction in "I'm Dancing as Fast as I Can"; penned by husband Rabe

Portrayed a flaky lawyer in Costa-Gavras' disappointing "Hanna K"

Joined an ensemble cast for the critically-acclaimed "Shy People"

Played Judge Louise Parker in NBC miniseries "Trial: The Price of Passion"

Acted the part of Kitty Menendez in the TV movie "Honor Thy Father and Mother: The True Story of the Menendez Murders" (FOX)

Had a supporting role as Matthew Perry's mother in "Fools Rush In"

Made a memorable guest appearance as a lawyer with questionable ethics on the NBC drama "Law & Order"

Played the matriarch of an Irish Catholic family on the NBC drama "Trinity"

Had a recurring role on the FOX comedy "Ally McBeal" as the title character's mother

Had featured role in short-lived NBC sitcom "Leap of Faith"

Earned an Emmy nomination for her guest-starring role on "Nip/Tuck" (FX)

Played the wife of an unorthodox psychiatrist in "Running with Scissors"; based on the personal memoirs of Augusten Burroughs

Cast as Letitia Darling on ABC's short-lived series "Dirty Sexy Money"