Film debut, "The Ages of Lulu", directed by Bigas Luna

Co-starred in Pedro Almodovar's "High Heels"

Reteamed with direcor Luna for "Jamon, Jamon"

Portrayed an oversexed man in Luna's "Golden Balls/Huevos de Oro"

Delivered change of pace turns in "The Detective and Death/El Detective y la Muerte" and "Numbered Days/Dias Contados"

Starred in "Mouth to Mouth/Boca a Boca"; released in USA in 1997

Reteamed with Almodovar for "Live Flesh"

English-language debut opposite Rosie Perez in "Perdita Durango"

Served as executive producer and star of "Los Lobos de Washington"

Starred as Cuban writer Reinaldo Arenas in "Before Night Falls"; received Best Actor Academy Award nomination

Had featured role in "The Dancer Upstairs", directed by John Malkovich; screened at Sundance

Co-starred in the award-winning feature "Monday's in the Sun"

Appeared opposite Tom Cruise in the thriller "Collateral"

Starred in "Mar Adentro/The Sea Inside" about the Life story of Spaniard Ramón Sampedro, who fought a 30-year campaign to win the right to end his life with dignity; received a Golden Globe nomination for Best Lead Actor (Drama)

Cast in Andy Garcia's independent film "The Lost City," centered around a club owner in Havana, Cuba, during the 50's

Played the sinister monk, Brother Lorenzo in Milos Forman's "Goya's Ghosts"

Offered an award winning performance as a murderous drug runner in the Coen brothers' "No Country for Old Men"

Played a lovesick romantic in Mike Newell's adaptation of "Love in the Time of Cholera"

Co-starred with Penélope Cruz and Scarlett Johansson in Woody Allen's "Vicky Cristina Barcelona"

Nominated for the 2008 Independent Spirit Award for Best Male Lead (“Vicky Cristina Barcelona”)

Nominated for the 2008 Golden Globe Award for Best Performance by an Actor in a Motion Picture – Musical or Comedy (“Vicky Cristina Barcelona”)