Stand-up comedian and actress Janeane Garofalo was the poster child for dry and caustically witty women in film and television in the late 1980s and early 1990s. Her self-deprecating humor and hipster style endeared her to college age audiences, but as her fame grew, Garofalo found it uncomfortable – if not downright impossible – to work within the Hollywood system. She eventually retreated from the mainstream, settling into a variety of roles, including a radio host on the liberal Air America network, where her comments drew considerable fire from the conservative majority.

Born Sept. 26, 1964