Born in Washington, DC

Raised in Wheaton, IL, and in Seattle, WA

TV debut in "Taking a Stand", an "ABC Afterschool Special"

Played Marty, Alex Keaton's final love interest, "Family Ties"

Film debut, "Vital Signs"

Broadway debut, "I Hate Hamlet"

Won acclaim (and a Tony Award) for her co-starring role in the Broadway production of "An Inspector Calls"

Ensemble cast member of "Kansas City", directed by Robert Altman

Made TV series debut in ABC ensemble drama "Relativity"

Starred in the controversial "Happiness", directed by Todd Solondz

Appeared in the Sundance screened "Songcatcher" as the schoolteacher sister of the lead character

Had recurring role of a plastic surgeon dating Niles Crane on the hit sitcom "Frasier" (NBC)

Cast as a neurotic actress in "The Anniversary Party"

Cast opposite Jim Carrey in "Eternal Sunshine of the Spotless Mind"

Cast in Todd Field's "Little Children"

Co-starred with Jodie Foster in the crime drama, "The Brave One"