Born in Indiana, where her father taught chemical engineering at Purdue University

At age nine, moved with family to South Africa where her father taught at the University of Potchesstroom

Won a contract with South African National Theatre; spent three years performing with the group

Professional acting debut as Juliet in the National Theatre Company production of "Romeo and Juliet"

American feature debut, "Mutator/Time of the Beast" (released straight-to-video)

Played a major supporting role in the progressive South African-produced film, "A Private Life"

Moved to Los Angeles from South Africa

American TV debut, "Till Death Us Do Part" (NBC)

First released American feature, Sam Raimi's "Army of Darkness"

Had a memorable role in "Schindler's List" as the Jewish maid

Was the female lead in the fact-based drama "Murder in the First"

Starred in the period drama "Feast of July"

Portrayed a heroic schoolteacher in the feature adaptation of Roald Dahl's children's fantasy "Matilda"

Played a theology prpfessor embroiled in a murder invesitation in the supernatural mystery "Fallen"

Essayed the part of a femme fatale in Robert Altman's adaptation of John Grisham's "The Gingerbread Man"

Co-starred in Patricia Rozema's reworking of Jane Austen's "Mansfield Park"

Played a dual role in the futuristic drama "Bicentennial Man"

Had a supporting role in the film adaptation of "Bridget Jones's Diary"

Co-starred in the CBS drama series "Citizen Baines"

Featured in the haunted house thriller "13 Ghosts"

Reteamed with Kenneth Branagh in the historical miniseries "Shackelford" (A&E)

Cast in the drama feature "The Emperor's Club"

Starred with Alessandro Nivola in the southern drama "Junebug"; premiered at Sundance

Guest-starred on the ABC drama, "Grey's Anatomy" as Dr. Derek Shepherd's (Patrick Dempsey) sister

Co-starred in the dramatic thriller, "Fracture" opposite Anthony Hopkins and Ryan Gosling

Cast as a wife seeking couples therapy with her husband in the HBO drama series "In Treatment"