Born in Syracuse, New York

Raised in Maryland and Lynchburg, Virginia

Appeared in regional theater productions as a teenager

Starred in off-Broadway play "Not About Heroes" opposite Edward Herrmann, directed by Dianne Wiest

Feature film debut "Planes, Trains and Automobiles"

Feature film debut, uncredited role, in "Ishtar"

First credited role in "Planes, Trains and Automobiles"

Broadway debut, "Eastern Standard"

TV series debut as regular, "Murder One" (ABC)

Cast in the ensemble of the NBC drama series "Feds"

Starred in Todd Solondz's controversial feature "Happiness"

Appeared in "Random Hearts"

Reunited with occasional co-star Patricia Clarkson in "Simply Irresistable"

Had featured role in "The Cell"

Acted in the Off-Broadway production of "What the Butler Saw"

Offered a strong turn as Robert McNamara in the historical drama "13 Days"

Co-starred as a hardnosed FBI agent in "Along Came a Spider"

Returned to the NYC stage in Tony Kushner's "Homebody/Kabul"

Appeared in "Changing Lanes" starring Samuel L. Jackson and Ben Affleck

Appeared with Tom Hanks and Paul Newman in "Road to Perdition"

Cast in Chris Rock's directorial debut "Head of State"

Cast as Ed Smart in the Television movie "The Elizabeth Smart Story" based on the true story of the kidnapping of teenager Elizabeth Smart

Cast as Dr. Curt Connors in "Spider-Man 2"

Acted opposite Liam Neeson in Bill Condon's "Kinsey" the story of Alfred Kinsey, a pioneer in the area of human sexuality research

Cast in Richard Shepard's "The Matador," with Pierce Brosnan and Greg Kinnear

Directed the Chautauqua Theater Company's production of "The Art of Coarse Acting"

Reprised role of Dr. Curt Connors in Sam Raimi's "Spider-Man 3"

Played the golf-loving absentee dad in the Canadian zombie film, "Fido"

Cast opposite Nathan Lane and Laurie Metcalf in the Broadway production of David Mamet's "November"