Acted in television commercials as a baby

TV-movie debut in "Bogie" (CBS); played Leslie Bogart as a child

Made first film appearance in a bit part in "Altered States"

Played Gertie, the younger sister, in "E.T., The Extra-Terrestrial"

Starting drinking at age nine

Played the title character in the sci-fi thriller "Firestarter"

Starred as a young girl divorcing her parents in "Irreconcilable Differences"

Started smoking marijuana

Starred in the NBC TV remake of "Babes in Toyland"

Began abusing cocaine

Institutionalized in a rehab center-cum-mental institution after a failed suicide attempt

Lived with musician and recovering addict David Crosby and his wife Jan for close to a year after her treatment

At age 15, filed papers to become legally emancipated from her parents

Lived with film director Tamra Davis and her husband briefly

First starring film role, "Poison Ivy"

TV series debut as regular, had featured role in the short-lived summer serial "2000 Malibu Road" (CBS)

Directed by Davis in "Guncrazy" (shown at film festivals before airing on Showtime prior to its 1993 theatrical release)

Played 'Long Island Lolita' Amy Fisher in the ABC TV-movie, "The Amy Fisher Story"

Founded the production company, Flower Films, Inc

Cast as the flirtatious Holly in "Boys on the Side," also featuring Whoopi Goldberg and Mary-Louise Parker

Starred opposite Chris O'Donnell as his free-spirited, mentally ill romantic interest in "Mad Love"

Made cameo appearance as a high school student targeted by the killer in "Scream"

Played featured role as Edward Norton's fiancee in Woody Allen's "Everyone Says I Love You"; had singing voice dubbed

Starred opposite Adam Sandler in the popular romantic comedy "The Wedding Singer"

Played a character based on Cinderella in the romance "Ever After"

Starred as an awkward twentysomething reporter who returns to high school for an undercover assignment in "Never Been Kissed"

Co-starred with Cameron Diaz in big screen version of the 1970s TV series "Charlie's Angels"

Executive produced and played supporting role of an English teacher in the critically acclaimed film "Donnie Darko"

Played a teenage mother in a failed marriage with the drug-addicted father (based on the real-life story of Beverly D'Onofrio) in Penny Marshall's "Riding in Cars With Boys"; also executive produced

Played the female lead in George Clooney's directorial debut, "Confessions of a Dangerous Mind"

Reprised role in "Charlie's Angels: Full Throttle"; made under her production banner, Flower Films

Reunited with Adam Sandler for the comedy "50 First Dates," playing a chronic amnesiac

Co-starred with Jimmy Fallon in the Americanized version of Nick Hornby's "Fever Pitch," directed by the Farrelly Brothers

Starred opposite Hugh Grant in the romantic comedy "Music & Lyrics"

Co-starred with Eric Bana in "Lucky You," a drama directed by Curtis Hanson (lensed 2005)