Studied ballet with Maria Tallchief as a child

Made film debut in Brian De Palma's "The Fury"

Moved to Los Angeles at age 19

Played first major role on television in the TV-movie, "Paper Dolls" (ABC)

Cast as an android in the sci-fi classic "Blade Runner"

Notable career landmark: playing the mermaid heroine of "Splash"

Portrayed the leading cave woman in the film "Clan of the Cave Bear"

Had title role opposite Steve Martin in "Roxanne"; film is a modern update of "Cyrano de Bergerac"

Co-starred in Oliver Stone's "Wall Street"

Had supporting role in Woody Allen's "Crimes and Misdemeanors"

Played a wallflower southerner in the ensemble, "Steel Magnolias"

Formed her own production company, Girlie Pictures

Acted alongside Aidan Quinn, Tom Berenger and Kathy Bates in "At Play in the Fields of the Lord"

Starred opposite Chevy Chase in "Memoirs of an Invisible Man"

Wrote, produced and directed short film, "The Last Supper"

Played title part in the HBO original "Attack of the 50 Ft. Woman"; also co-produced

Cast as Jack Lemmon's daughter in the feature comedy "Grumpy Old Men"

Offered a change of pace turn as an on-the-run outlaw alongside Keith Carradine in "The Tie That Binds"

Reprised role in the sequel "Grumpier Old Men"

Cast as Melanie Griffith's sister in the comedy "Two Much"

Was featured in the CBS miniseries "Mario Puzo's 'The Last Don'"

Took supporting role in Robert Altman's "The Gingerbread Man"

Played the Grace Kelly role in the small screen reamke of "Rear Window" (ABC)

Had female lead in the feature film "My Favorite Martian"

Portrayed a stripper in "Dancing at the Blue Iguana"; screened at Toronto Film Festival; released in USA in 2001

Made London stage debut in revival of "The Seven Year Itch"

Played small role as the unhappy wife of an aspiring country singer in "Jackpot"

Played Mandy Moore's mother in teen romance film "A Walk to Remember"

Cast in the feature "Northfolk"

Played assassin Elle Driver opposite Uma Thurman in Quentin Tarantino's "Kill Bill"; film released in two Volumes "Kill Bill Vol. 1" (2003) and "Kill Bill Vol.2" (2004)

Starred in John Sayles' political satire "Silver City"

Cast as Garry Marshall's spacey younger girlfriend in the indie comedy "Keeping Up with the Steins"