Raised in a community on Philadelphia's Main Line

Traveled to Berlin as a foreign exchange music student; was present when the Berlin Wall was erected

Sang soprano with a jazz group at Baggy Pants in Stowe, Vermont

Professional stage debut as Laura in "The Glass Menagerie"

Spent one season as a member of the Theatre Company of Boston

NYC debut in the Off-Broadway play "The Infantry"

Spent part of the theater season acting with Trinity Square Repertory Company in Providence, Rhode Island

Was cast in first Broadway show, the musical "Mata Hari"; had featured role; show closed during out-of-town tryout

Garnered attention for her performance in the Lincoln Center productions of "Summertree" (1968) and "The Miser" (1969)

TV debut in "Day Tripper" episode of "N.Y.P.D" (ABC)

Breakthrough stage role as the kooky, sexually liberated teenage divorcee Jill Tanner, who befriends her blind male neighbor, in "Butterflies Are Free"; received Tony Award

Had supporting role in NBC production of the Broadway musical "George M!"

Played featured role in the ABC movie "Dr. Cook's Garden", starring Bing Crosby

Film acting debut, "To Kill a Clown", co-starring Alan Alda

Made feature singing debut as Martha Jefferson in "1776", opposite Ken Howard

Appeared on "Columbo" (NBC)

Starred as Amanda in the short-lived ABC sitcom, "Adam's Rib", opposite Ken Howard

Had leading role of a woman who comes betweeen two friends in "Lovin' Molly"

Portrayed Zelda to Richard Chamberlain's F Scott Fitzgerald in the ABC drama "F. Scott Fitzgerald and 'The Last of the Belles'"

Began on-going association with the Williamstown Theatre Festival; appeared as Nina in Chekhov's "The Seagull"; production filmed and aired on public television's "Theater in America" series; co-stared with Frank Langella

Again paired with Langella in the Williamstown production of Tennessee Williams' "Eccentricities of a Nightingale"; production filmed and aired on "Theater in America"

Was leading lady to Jeff Bridges in the amiable comedy "Hearts of the West"

Reteamed with Alan Alda in a memorable episode of "M*A*S*H*" (CBS)

Co-starred in the sequel "Futureworld"

Had lead in "The New York Idea", staged at the Brooklyn Academy of Music

Portrayed Elizabeth Custer, the general's wife, in "The Court-Martial of General George Armstrong Custer" (ABC), a fictionalized speculation of what might have happened had Custer not died at Little Big Horn

Earned critical praise as Eleanor Gehrig in the NBC biographical drama, "A Love Affair: The Eleanor and Lou Gehrig Story"

With Michael Moriarty, starred in "Too Far to Go", adapted from short stories by John Updike; originally aired on NBC; briefly released theatrically

Delivered a strong turn as the devoted wife of a military officer in "The Great Santini"

Returned to Broadway appearing alongside Raul Julia and Roy Scheider in Harold Pinter's "Betrayal"; earned Tony nomination

Starred in the Lincoln Center revival of "The Philadelphia Story"

Portrayed the wife of German architect Albert Speer in the ABC miniseries "Inside the Third Reich"

Made guest appearance in an episode of "St. Elsewhere" (NBC)

Cast as Annie Sullivan in the syndicated "Helen Keller -- The Miracle Continues"

Offered nice turn as the wife of a philandering attorney (Anthony Hopkins) who was plotting to kill her in the three-character drama "Guilty Conscience" (CBS)

Played the matriarch of a Jewish family in the film version of Neil Simon's semi-autobiographical "Brighton Beach Memoirs"; Judith Ivey co-starred as her sister

Co-starred with Richard Chamberlain and Judith Ivey in a revival of Noel Coward's "Blithe Spirit"; played Elvira

Earned Tony nomination as Blanche Du Bois in a stage revival of "A Streetcar Named Desire"

Appeared opposite Kevin Kline in the New York Shakespeare Festival's summer production of "Much Ado About Nothing" in NYC's Central Park

Played the co-owner of a NYC restaurant in the NBC drama "Tattinger's"; series was cancelled after a brief run and retooled as a sitcom called "Nick & Hillary" (NBC, 1989) which lasted only a handful of episodes

Appeared in Woody Allen's "Another Woman"

Cast as the mother of a child molested by a priest in the HBO drama "Judgment"

Supported Paul Newman and Joanne Woodward in the Merchant Ivory production "Mr. & Mrs. Bridge"

Second film with Woody Allen, "Alice"

Acted alongside Gwyneth Paltrow in "Picnic" at Williamstown Theatre Festival

Gave a fine performance as Nick Nolte's wife in "The Prince of Tides"

Played the victim of a an attempted murder who begins to suspect her son of the crime in the NBC miniseries "Cruel Doubt"; daughter Gwyneth Paltrow played her onscreen daughter

Played Juliette Lewis' mother in Woody Allen's "Husbands and Wives"

Had featured role in the CBS miniseries "Oldest Confederate Widow Tells All"

Portrayed Arkadina in Williamstown production of "The Seagull" with daughter Gwyneth Paltrow as Nina

Appeared Off-Broadway in A R Gurney's stage comedy "Sylvia"

Starred opposite Jason Robards in Pinter's "Moonlight"

Portrayed the matriarch of a troubled family in "The Myth of Fingerprints"; screened at Sundance; Roy Scheider co-starred as the family patriarch

Voiced Martha Jefferson in the PBS documentary "Thomas Jefferson", directed by Ken Burns

Cast as a Holocaust survivor in "A Call to Remember", aired on Starz! and Encore

Was one of the museum employees taken hostage by a disgruntled former security guard (John Travolta) in "Mad City"

Had lead role in ill-fated revival of "The Deep Blue Sea"

Played a Janet Reno-like character in a cameo in "The X-Files"

Hosted "Sophisticated Ladies: Charleston and Savannah With Blythe Danner" (PBS)

Co-starred in "Anne Tyler's 'Saint Maybe'" (CBS), a "Hallmark Hall of Fame" production

Provided the voice of the title character, a crime-solving tiger cat in "Murder She Purred: A Mrs. Murphy Mystery" (ABC)

Starred as a woman who accidentally killed her daughter in the taut drama "The Farmhouse"; screened at Gen Art Film Festival; aired on Sundance Channel in 1999

Played Kate Capshaw's mother in "The Love Letter"

Co-starred with Edward Herrmann in a staged reading of A R Gurney's "Ancestral Voices"

Appeared as Robert De Niro's wife in "Meet the Parents"

Played the mother of Cameron Diaz and Jordana Brewster in "The Invisible Circus"

Cast as Phyllis in the all-star Broadway revival of "Follies", featuring Judith Ivey, Treat Williams and Gregory Harrison; received Tony nomination

Cast in the recurring role as Will's mother on the NBC comedy "Will & Grace"; earned an Emmy nomination for Best Guest Actress in 2005

Cast as Corinne Mulvaney in the Lifetime drama "We Were The Mulvaney's"

Cast as Dr. Harriet Lanning in the short-lived CBS medical drama "Presidio Med"

Portrayed Sylvia Plath's mother opposite her real life daughter Gwyneth Paltrow in "Sylvia"

Starred as Hank Azaria's mother in the Showtime drama "Huff"

Reprised her role as Dina Byrnes for the comedy sequel "Meet the Fockers"

Starred in the TV movie "Back When We Were Grownups" (CBS); received a Golden Globe nomination for Best Actress in a Mini Series or TV movie

Co-starred in "The Last Kiss" directed by Tony Goldwyn and scripted by Paul Haggis

Earned an Emmy nomination for Best Guest Actress in a Comedy Series for "Will & Grace"