Born in Puerto Rico

Family moved to Pennsylvania when Del Toro's mother died

Moved to Los Angeles to pursue acting

Made first TV appearance in an episode of "Miami Vice" (NBC)

Feature film debut, "Big Top Pee-wee" as Duke, the dog-faced boy

Played a Bond villain in "License to Kill"

Made TV miniseries debut as a drug lord in "Drug Wars: The Camarena Story" (NBC)

Had supporting role in Sean Penn's directorial debut, "The Indian Runner"

Played key villainous role in "Christopher Columbus: The Discovery"

Made short-film writing and directing debut, "Submission"; screened at the Venice Film Festival

Breakthrough role as the mumbling, wisecracking Fred Fensterin in Bryan Singer's "The Usual Suspects"

Portrayed a streetwise buddy of the titular artist in "Basquiat"; helmed by Julian Schnabel

Played a hot-tempered rival to a trio of brothers involved with the Mafia in Abel Ferrara's "The Funeral"

Garnered favorable reviews as a car thief turned inadvertent kidnapper in the Alicia Silverstone vehicle "Excess Baggage"

Cast as Dr. Gonzo, the lawyer for a Hunter S Thompson-like journalist (Johnny Depp), in Terry Gilliam's film adaptation of Thompson's book "Fear and Loathing in Las Vegas"

Reunited with "Usual Suspects" screenwriter Christopher McQuarrie for "The Way of the Gun"

Played diamond thief, Franky Four Fingers in Guy Ritchie's hip caper comedy "Snatch"

Portrayed a Mexican border cop struggling to remain honest amid corruption in Steven Soderbergh's "Traffic"

Re-teamed with director Sean Penn, playing a mentally challenged Native American in "The Pledge"

Co-starred with Sean Penn and Naomi Watts as an ex-convict in "21 Grams"; directed by Alejandro González Iñárritu and written by Guillermo Arriaga; earned Oscar and SAG nominations for Best Supporting Actor

Cast as Jackie Boy, a dirty cop with a penchant for violence in "Sin City" an adaptation of Frank Miller's graphic novels; co-directed by Miller and Robert Rodriguez

Co-starred with Halle Berry in "Things We Lost in the Fire"

Portrayed the title character in Steven Soderbergh's two part biopic, "Che," about the life of Marxist revolutionary Ernesto Guevara