Moved to Ireland as a young child and lived in an estate in Galway

Moved to London at age ten

Auditioned for the role of Juliet in Franco Zeffirelli's film version of "Romeo and Juliet"

Feature acting debut, an uncredited appearance in her father, John Huston's "Sinful Davey"

First starring role, "A Walk with Love and Death"; directed by her father (who also co-starred as her uncle)

Moved to NYC after mother's death and was an understudy for Marianne Faithful in the Broadway production of "Hamlet"

Modeled for photographer (an old friend of Huston's mother) Richard Avedon in a 30-page fashion shoot for Vogue magazine

Moved to Los Angeles to live with off-screen love, Jack Nicholson

Returned to the screen in Elia Kazan's "The Last Tycoon"; first film with Jack Nicholson

Second film with Nicholson, Bob Rafelson's remake of "The Postman Always Rings Twice"

Acted in episodes of "Laverne and Shirley" (ABC)

Appeared in Rob Reiner's feature directing debut, "This Is Spinal Tap"

Career received a boost when she was cast as an Amazon with guns in "The Ice Pirates"

TV-movie debut, "The Cowboy and the Ballerina" (CBS)

Breakthrough screen role as the Mafia princess in John Huston's "Prizzi's Honor"; third on-screen collaboration with Nicholson

Played title role in the Los Angeles stage production of "Tamara"

Joined Michael Jackson and Dick Shawn in Francis Ford Coppola's 17-minute, 3-D musical "Captain Eo" (produced for the Disney theme parks)

Re-teamed with Coppola in her first leading role, "Gardens of Stone"

Played a woman in a loveless marriage in John Huston's final film, "The Dead"; screenplay was adapted by brother, Tony from the short story of the same name by James Joyce

Acted in half-brother Danny Huston's "Mr. North"; co-adapted by father, John Huston

Received a Best Supporting Oscar nomination as a Nazi concentration camp survivor in Paul Mazursky's "Enemies, a Love Story"

First film with director Woody Allen, "Crimes and Misdemeanors," playing the desperate mistress of Martin Landau

Cast as as Clara Allen in the CBS miniseries, "Lonesome Dove" (adapted from Larry McMurtry's novel); received an Emmy nomination for Lead Actress in a Miniseries

Received a Best Actress Academy Award nomination for her role as Lily Dillon in "The Grifters"

Acted the part of the Grand High Witch in Nicolas Roeg's "The Witches"

Portrayed matriarch, Morticia Addams in "The Addams Family"

Appeared as herself in Robert Altman's "The Player"

Reprised role of Morticia for "Addams Family Values"

Re-teamed with Woody Allen for "Manhattan Murder Mystery"

Offered a strong performance as the mother of an autistic child in the ABC miniseries "Family Pictures"

Portrayed Doctor Betsy Reisz in the acclaimed HBO movie, "And the Band Played On" that follows the course of the AIDS crisis

Re-teamed with Nicholson to play an estranged couple in Sean Penn's "The Crossing Guard"

Portrayed Calamity Jane in the CBS miniseries "Buffalo Girls" (adapted from Larry McMurtry's novel); received an Emmy nomination for Supporting Actress in a Miniseries

Made directorial debut with "Bastard Out of Carolina" (originally filmed for TNT, but they would not air it due to its content; later aired on Showtime); received an Emmy nomination for Directing

Played Vincent Gallo's Buffalo Bills-crazed mom in Gallo's "Buffalo 66"

Portrayed the evil stepmother in Andy Tennant's take on the Cinderella story "Ever After"

Acted in Danny Cannon's mediocre crime film "Phoenix" (HBO), portraying Ray Liotta's love interest

Directed, co-produced and starred in "Agnes Browne" as a widowed mother of seven in 1960s Ireland

Appeared in James Ivory's "The Golden Bowl" (based on the Henry James novel)

Portrayed the Lady in the Lake in the TNT retelling of the Arthurian legend "The Mists of Avalon"

Played the matriarch in a family of failed geniuses in Wes Anderson's "The Royal Tenenbaums"

Starred opposite Clint Eastwood in "Blood Work"

Co-starred with Hilary Swank in the HBO movie "Iron Jawed Angels," about the American women's suffrage movement during the early 1900s; received an Emmy nomination for Supporting Actress

Co-starred with Bill Murray in Wes Anderson's "The Life Aquatic with Steve Zissou" as Zissou's (Murray) estranged wife

Directed Rosie O'Donnell and Andie MacDowell in the CBS movie "Riding the Bus With My Sister"

Guest-starred as an unorthodox psychiatrist in a four episode stint on the Showtime series "Huff"

Cast in Terry Zwigoff's adaptation of Daniel Clowes' comic story "Art School Confidential"

Co-starred with Liam Neeson and Pierce Brosnan in the western "Seraphim Falls"

Played a missing persons investigator in a six-episode story arc on "Medium" (NBC); received an Emmy nomination for Guest Actress in a Drama

Cast as Sam Rockwell's mother in the film "Choke," based on the novel by Chuck Palahniuk