Worked at McDonald's while in high school

Dropped out of college at age 20

Moved to New York City

Signed by Elite Model Managment

Moved to Paris to work as an Elite model

Feature acting debut, "Greystoke: The Legend of Tarzan, Lord of the Apes"; played Jane; her natural Southern accent proved a problem and her dialogue was later dubbed by Glenn Close

Feature acting debut with her own voice, "St. Elmo's Fire"

Had breakthrough screen role in "sex, lies and videotape"

Starred with Gerard Depardieu in the romantic comedy "Green Card"

TV acting debut, "A Domestic Dilemma", a segment of HBO's "Women and Men II"

Played opposite Bruce Willis in the box-office bomb "Hudson Hawk"

Featured in the ensemble of Robert Altman's "Short Cuts"

Played leading lady to Bill Murray in Harold Ramis' "Groundhog Day"

Co-starred opposite Hugh Grant in the Oscar-nominated Best Picture "Four Weddings and a Funeral"

Headlined Diane Keaton's "Unstrung Heroes" as a dying mother

Portrayed Michael Keaton's wife in Ramis' "Multiplicity"

Appeared as a skeptical reporter who becomes romantically involved with William Hurt in "Michael"

Played Bill Pullman's wife in "The End of the Violence"

Starred in "Shadrach" with Harvey Keitel

Executive produced and co-starred with Andy Garcia in the comedy "Just the Ticket"

Realized her dream of acting with Miss Piggy in "Muppets from Space"

Played the wife of blocked screenwriter Albert Brooks in Brooks' "The Muse"

Profiled in Lifetime's "Intimate Portrait: Andie MacDowell"

Co-starred in the HBO adaptation of the Pulitzer-winning play "Dinner With Friends"

Had featured role as Warren Beatty's vivacious paramour in "Town & Country", which also reteamed her with Keaton

Appeared in the comedy "Beauty Shop" starring Queen Latifah

Co-starred with Rosie O'Donnell in the CBS movie "Riding the Bus With My Sister," based on the book about her characters challenging relationship with her developmentally disabled sibling; directed by Anjelica Huston

Voiced Etta the Hen in the animated feature, "Barnyard"