Raised in North Carolina

In the 1980s, moved to Chicago

Began performing with brother David at the famed improv troupe Second City

In early 1990s, relocated to NYC

Acted on stage in "Jamboree, Stump the Host"

Co-created (also performed) the Comedy Central series "Exit 57"; worked with Second City alums Stephen Colbert, Paul Dinello and Mitch Rouse

Starred on stage in "One Woman Shoe"

Film debut in small role in "Commandments"

Originated a role in the play "The Country Club" in New Haven; recreated part Off-Broadway in 1999

Appeared on the big screen in "Six Days, Seven Nights"

Co-wrote and co-starred in the short film "Wheels of Fury" directed by Paul Dinello, Dan Dinello and Mitch Rouse

Was featured in Paul Rudnick's Off-Broadway play "The Most Fabulous Story Ever Told"

Breakthrough TV role as Jerri Blank in the Comedy Central sitcom, "Strangers with Candy"; co-created with Colbert and Dinello

Wrote and starred in "The Book of Liz" on stage

Had recurring role on the NBC sitcom "Just Shoot Me"

Played multiple roles in the Off-Broadway comedy "Wonder of the World"

Had recurring role as a book publisher on the HBO sitcom "Sex and the City"

Cast in a recurring role on USA's quirky detective series "Monk"

Played a wealthy hotel guest in "Maid in Manhattan"

Appeared in the comedy "My Baby's Daddy"

Guest-hosted CBS' "The Late Late Show" to fill in for the departed Craig Kilborn

Cast opposite Nicole Kidman and Will Ferrell in the remake of the classic 60's TV show "Bewitched"

Voiced Foxy Loxy in the animated feature "Chicken Little"

Starred in the big-screen version of "Strangers with Candy" a prequal to the taboo-bashing series, which she co-created with Colbert and Dinello

Appeared in Jeff Garlin's feature directing debut, "I Want Someone to Eat Cheese with"

Voiced Cinderella in "Shrek the Third"

Appeared in the Sundance screened "Snow Angels"

Featured in David Munro's "Full Grown Men"