Made stage debut in "Rumpelstiltskin" at the Actor's Workshop in San Francisco

Made Off-Broadway debut at age seventeen, in a production of "And Chocolate on Her Chin"

Appeared in first TV-movie, "Panache," an ABC pilot based on "The Three Musketeers"

Made an unforgettable film debut as Sue Snell in Brian DePalma's "Carrie"

Played a lead role in the miniseries epic "Once an Eagle" (NBC), opposite Sam Elliott and Glenn Ford

Re-teamed with De Palma for "The Fury"

Made Broadway debut, succeding Jane Seymour as Constanze, in "Amadeus"

Returned to Broadway, opposite Rex Harrison, in an acclaimed revival of George Bernard Shaw's "Heartbreak House"

Received a Best Supporting Actress Oscar nomination for her performance as the bride-to-be Hadass in Barbra Streisand's directorial debut "Yentl"

Starred as an Indian princess romanced by a British calvary officer in the HBO miniseries "The Far Pavillions"

Played one of Dudley Moore's pregnant wives in the Blake Edwards comedy "Micki & Maude"

Reprised her stage role for the Showtime production of "Heartbreak House"

Portrayed Anna Anderson, a woman who claimed to be the daughter of Russian Czar Nicholas II, in NBC's miniseries "Anastasia: The Mystery of Anna"

Appeared Off-Broadway in Athol Fugard's "The Road to Mecca"

Starred as a upscale New Yorker who is matched with a pickle saleman in "Crossing Delancey"

Provided the singing voice of Jessica Rabbit in the combination live action-animated feature "Who Framed Roger Rabbit"

Starred in Bruno Barreto's "A Show of Force"; became romantically involved with Baretto during production

Headlined the LA production of Wendy Wasserstein's award-winning play "The Heidi Chronicles"

Starred in the Broadway production of Arthur Miller's "Broken Glass"

Re-teamed with Baretto for "Carried Away"

Returned to Broadway, alongside Lili Taylor and Jeanne Tripplehorn, in Chekhov's "Three Sisters"

Appeared in Woody Allen's "Deconstructing Harry"

Co-starred as a tough-talking FBI agent in Barreto's "One Tough Cop"

Reprised role of Sue Snell in "The Rage: Carrie II"

Re-teamed with Barreto for "Bossa Nova"

Appeared as the wife of a drug czar in Steven Soderbergh's "Traffic"

Acted in "The Vagina Monologues" in London

Had featured role in "13 Conversations About One Thing"; screened at Toronto; shown at the 2002 Sundance Film Festival

Played the recurring role of Emily Sloane in the ABC spy series "Alias"

Cast in the family feature drama "Tuck Everlasting"

Starred opposite Robert De Niro and Dakota Fanning in the thriller "Hide and Seek"

Appeared on Broadway in Tom Stoppard's "The Coast of Utopia" at New York's Lincoln Center

Played Rose Byrne's mother in "Adam"